Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weiser-Fuchs, MT; Maggauer, E; van, Poppel, MNM; Csapo, B; Desoye, G; Köfeler, HC; Groselj-Strele, A; Trajanoski, S; Fluhr, H; Obermayer-Pietsch, B; Jantscher-Krenn, E.
Human Milk Oligosaccharides in Maternal Serum Respond to Oral Glucose Load and Are Associated with Insulin Sensitivity.
Nutrients. 2023; 15(18):
Doi: 10.3390/nu15184042
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- Führende Autor*innen der Med Uni Graz
- Fluhr Herbert
- Weiser-Fuchs Marie-Therese
- Co-Autor*innen der Med Uni Graz
- Csapo Bence Daniel
- Desoye Gernot
- Groselj-Strele Andrea
- Jantscher-Krenn Evelyn
- Köfeler Harald
- Obermayer-Pietsch Barbara
- Trajanoski Slave
- Van Poppel Mireille Nicoline Maria
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- Abstract:
- (1) Background: Pregnancy presents a challenge to maternal glucose homeostasis; suboptimal adaptations can lead to gestational diabetes mellitus (GDM). Human milk oligosaccharides (HMOs) circulate in maternal blood in pregnancy and are altered with GDM, suggesting influence of glucose homeostasis on HMOs. We thus assessed the HMO response to glucose load during an oral glucose tolerance test (OGTT) and investigated HMO associations with glucose tolerance/insulin sensitivity in healthy pregnant women. (2) Methods: Serum of 99 women, collected at 0 h, 1 h and 2 h during a 75 g OGTT at 24-28 gestational weeks was analyzed for HMOs (2'FL, 3'SLN, LDFT, 3'SL) by HPLC; plasma glucose, insulin and C-peptide were analyzed by standard biochemistry methods. (3) Results: Serum 3'SL concentrations significantly increased from fasting to 1 h after glucose load, while concentrations of the other HMOs were unaltered. Higher 3'SL at all OGTT time points was associated with a generally more diabetogenic profile, with higher hepatic insulin resistance (HOMA-IR), lower insulin sensitivity (Matsuda index) and higher insulin secretion (C-peptide index 1). (4) Conclusions: Rapid increase in serum 3'SL post-oral glucose load (fasted-fed transition) indicates utilization of plasma glucose, potentially for sialylation of lactose. Associations of sialylated HMOs with a more diabetogenic profile suggest sustained adaptations to impaired glucose homeostasis in pregnancy. Underlying mechanisms or potential consequences of observed HMO changes remain to be elucidated.
- Find related publications in this database (using NLM MeSH Indexing)
- Pregnancy - administration & dosage
- Humans - administration & dosage
- Female - administration & dosage
- Glucose - administration & dosage
- Milk, Human - administration & dosage
- Insulin Resistance - administration & dosage
- Blood Glucose - administration & dosage
- C-Peptide - administration & dosage
- Diabetes, Gestational - administration & dosage
- Oligosaccharides - administration & dosage
- Insulin - administration & dosage
- Find related publications in this database (Keywords)
- human milk oligosaccharides
- pregnancy
- oral glucose tolerance test
- gestational diabetes mellitus
- 3 '-sialyllactose
- hexosamine biosynthetic pathway
- sialic acid
- insulin sensitivity