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SHR Neuro Cancer Cardio Lipid Metab Microb

Sung, MM; Byrne, NJ; Robertson, IM; Kim, TT; Samokhvalov, V; Levasseur, J; Soltys, CL; Fung, D; Tyreman, N; Denou, E; Jones, KE; Seubert, JM; Schertzer, JD; Dyck, JR.
Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure.
Am J Physiol Heart Circ Physiol. 2017; 312(4): H842-H853. Doi: 10.1152/ajpheart.00455.2016
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Co-authors Med Uni Graz: Byrne Nikole
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Abstract:: We investigated whether treatment of mice with established pressure overload-induced heart failure (HF) with the naturally occurring polyphenol resveratrol could improve functional symptoms of clinical HF such as fatigue and exercise intolerance. C57Bl/6N mice were subjected to either sham or transverse aortic constriction surgery to induce HF. Three weeks postsurgery, a cohort of mice with established HF (%ejection fraction <45) was administered resveratrol (~450 mg·kg^-1·day^-1) or vehicle for 2 wk. Although the percent ejection fraction was similar between both groups of HF mice, those mice treated with resveratrol had increased total physical activity levels and exercise capacity. Resveratrol treatment was associated with altered gut microbiota composition, increased skeletal muscle insulin sensitivity, a switch toward greater whole body glucose utilization, and increased basal metabolic rates. Although muscle mass and strength were not different between groups, mice with HF had significant declines in basal and ADP-stimulated O₂ consumption in isolated skeletal muscle fibers compared with sham mice, which was completely normalized by resveratrol treatment. Overall, resveratrol treatment of mice with established HF enhances exercise performance, which is associated with alterations in whole body and skeletal muscle energy metabolism. Thus, our preclinical data suggest that resveratrol supplementation may effectively improve fatigue and exercise intolerance in HF patients.NEW & NOTEWORTHY Resveratrol treatment of mice with heart failure leads to enhanced exercise performance that is associated with altered gut microbiota composition, increased whole body glucose utilization, and enhanced skeletal muscle metabolism and function. Together, these preclinical data suggest that resveratrol supplementation may effectively improve fatigue and exercise intolerance in heart failure via these mechanisms.
Find related publications in this database (using NLM MeSH Indexing): Animals - administration & dosage; Antioxidants - pharmacology; Energy Metabolism - drug effects; Exercise Tolerance - drug effects; Fatigue - prevention & control; Glucose - metabolism; Heart Failure - drug therapy, physiopathology; Insulin Resistance - administration & dosage; Male - administration & dosage; Mice - administration & dosage; Mice, Inbred C57BL - administration & dosage; Microbiota - administration & dosage; Muscle, Skeletal - drug effects; Oxidation-Reduction - administration & dosage; Oxygen Consumption - drug effects; Physical Conditioning, Animal - administration & dosage; Physical Exertion - drug effects; Resveratrol - administration & dosage; Stilbenes - pharmacology; Stroke Volume - drug effects
Find related publications in this database (Keywords): exercise tolerance; gut microbiome; heart failure; resveratrol