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SHR Neuro Cancer Cardio Lipid Metab Microb

Kentgens, AC; Kurz, JM; Mozun, R; Usemann, J; Pedersen, ESL; Kuehni, CE; Latzin, P; Moeller, A; Singer, F, , LuftiBus, In, the, School, (LUIS), Study, Group.
Evaluation of the Double-Tracer Gas Single-Breath Washout Test in a Pediatric Field Study.
Chest. 2024; 165(2):396-404 Doi: 10.1016/j.chest.2023.09.006 [OPEN ACCESS]
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Leading authors Med Uni Graz: Singer Florian
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Abstract:: BACKGROUND: The early life origins of chronic pulmonary diseases are thought to arise in peripheral small airways. Predictors of ventilation inhomogeneity, a proxy of peripheral airway function, are understudied in schoolchildren. RESEARCH QUESTION: Is the double-tracer gas single-breath washout (DTG-SBW) measurement feasible in a pediatric field study setting? What are the predictors of the DTG-SBW-derived ventilation inhomogeneity estimate in unselected schoolchildren? STUDY DESIGN AND METHODS: In this prospective cross-sectional field study, a mobile lung function testing unit visited participating schools in Switzerland. We applied DTG-SBW, fraction of exhaled nitric oxide (Feno), and spirometry measurements. The DTG-SBW is based on tidal inhalation of helium and sulfur-hexafluoride, and the phase III slope (SIII_He-SF6) is derived. We assessed feasibility, repeatability, and associations of SIII_He-SF6 with the potential predictors of anthropometrics, presence of wheeze (ie, parental report of one or more episode of wheeze in the prior year), Feno, FEV₁, and FEV₁/FVC. RESULTS: In 1,782 children, 5,223 DTG-SBW trials were obtained. The DTG-SBW was acceptable in 1,449 children (81.3%); the coefficient of variation was 39.8%. SIII_He-SF6 was independently but weakly positively associated with age and BMI. In 276 children (21.2%), wheeze was reported. SIII_He-SF6 was higher by 0.049 g.mol.L^-1 in children with wheeze compared with those without and remained associated with wheeze after adjusting for age and BMI in a multivariable linear regression model. SIII_He-SF6 was not associated with Feno, FEV₁, and FEV₁/FVC. INTERPRETATION: The DTG-SBW is feasible in a pediatric field study setting. On the population level, age, body composition, and wheeze are independent predictors of peripheral airway function in unselected schoolchildren. The variation of the DTG-SBW possibly constrains its current applicability on the individual level. TRIAL REGISTRATION: ClinicalTrials.gov; No.: NCT03659838; URL: www. CLINICALTRIALS: gov.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Child - administration & dosage; Prospective Studies - administration & dosage; Cross-Sectional Studies - administration & dosage; Gases - administration & dosage; Respiration - administration & dosage; Breath Tests - administration & dosage; Sulfur Hexafluoride - administration & dosage
Find related publications in this database (Keywords): adolescent; child; helium; lung function tests; small airway remodeling; sulfur hexafluoride; ventilation tests; wheezing