Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cano, Garcia, C; Tappero, S; Piccinelli, ML; Barletta, F; Incesu, RB; Morra, S; Scheipner, L; Baudo, A; Tian, Z; Hoeh, B; Chierigo, F; Sorce, G; Saad, F; Shariat, SF; Carmignani, L; Ahyai, S; Longo, N; Tilki, D; Briganti, A; De, Cobell, O; Dell'Oglio, P; Mandel, P; Terrone, C; Chun, FKH; Karakiewicz, PI.
In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery.
Ann Surg Oncol. 2023; 30(13):8770-8779
Doi: 10.1245/s10434-023-14246-0
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- Co-Autor*innen der Med Uni Graz
- Ahyai Sascha
- Scheipner Lukas
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- Abstract:
- BACKGROUND: This study aimed to test for temporal trends of in-hospital venous thromboembolism (VTE) and pulmonary embolism (PE) after major urologic cancer surgery (MUCS). METHODS: In the Nationwide Inpatient Sample (NIS) database (2010-2019), this study identified non-metastatic radical cystectomy (RC), radical prostatectomy (RP), radical nephrectomy (RN), and partial nephrectomy (PN) patients. Temporal trends of VTE and PE and multivariable logistic regression analyses (MLR) addressing VTE or PE, and mortality with VTE or PE were performed. RESULTS: Of 196,915 patients, 1180 (1.0%) exhibited VTE and 583 (0.3%) exhibited PE. The VTE rates increased from 0.6 to 0.7% (estimated annual percentage change [EAPC] + 4.0%; p = 0.01). Conversely, the PE rates decreased from 0.4 to 0.2% (EAPC - 4.5%; p = 0.01). No difference was observed in mortality with VTE (EAPC - 2.1%; p = 0.7) or with PE (EAPC - 1.2%; p = 0.8). In MLR relative to RP, RC (odds ratio [OR] 5.1), RN (OR 4.5), and PN (OR 3.6) were associated with higher VTE risk (all p < 0.001). Similarly in MLR relative to RP, RC (OR 4.6), RN (OR 3.3), and PN (OR 3.9) were associated with higher PE risk (all p < 0.001). In MLR, the risk of mortality was higher when VTE or PE was present in RC (VTE: OR 3.7, PE: OR 4.8; both p < 0.001) and RN (VTE: OR 5.2, PE: OR 8.3; both p < 0.001). CONCLUSIONS: RC, RN, and PN predisposes to a higher VTE and PE rates than RP. Moreover, among RC and RN patients with either VTE or PE, mortality is substantially higher than among their VTE or PE-free counterparts.
- Find related publications in this database (using NLM MeSH Indexing)
- Male - administration & dosage
- Humans - administration & dosage
- Venous Thromboembolism - administration & dosage
- Urologic Neoplasms - surgery
- Nephrectomy - administration & dosage
- Pulmonary Embolism - administration & dosage
- Hospitals - administration & dosage
- Risk Factors - administration & dosage