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SHR Neuro Cancer Cardio Lipid Metab Microb

Savva, A; Hama, A; Herrera-Lopez, G; Schmidt, T; Migliaccio, L; Steiner, N; Kawan, M; Fiumelli, H; Magistretti, PJ; Mcculloch, I; Baran, D; Gasparini, N; Schindl, R; Glowacki, ED; Inal, S.
Photo-Chemical Stimulation of Neurons with Organic Semiconductors
ADV SCI. 2023; Doi: 10.1002/advs.202300473 [OPEN ACCESS]
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Co-authors Med Uni Graz: Schindl Rainer; Schmidt Tony
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Abstract:: Recent advances in light-responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution-processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p-type semiconducting polymer PDCBT and the n-type semiconducting small molecule ITIC (a non-fullerene acceptor) are coated on glass supports, forming a p-n junction with high photosensitivity. Patch clamp measurements show that low-intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p-n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo-capacitive, photo-thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low-intensity photo-chemical intervention with neuron electrophysiology pave the way for developing wireless light-based therapy based on emerging organic semiconductors. Highly photosensitive, organic p-n junctions stimulate primary neurons via photochemical reactions, when illuminated with low-intensity light. The profound advantages of low-intensity, photo-chemical intervention with neuron electrophysiology, pave the way for developing wireless, light therapy, based on emerging organic semiconductors.image
Find related publications in this database (Keywords): non-fullerene acceptors; organic bioelectronics; photo-stimulation