Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bartsch, R; Rinnerthaler, G; Petru, E; Egle, D; Gnant, M; Balic, M; Sliwa, T; Singer, C.
Updated Austrian treatment algorithm for metastatic triple-negative breast cancer.
Wien Klin Wochenschr. 2024; 136(11-12):347-361
Doi: 10.1007/s00508-023-02254-9
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- Co-Autor*innen der Med Uni Graz
- Balic Marija
- Petru Edgar
- Rinnerthaler Gabriel
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- Abstract:
- Approximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and carries a significantly elevated risk of local and distant recurrence. In comparison with other breast cancer subtypes, there is a higher rate of visceral and brain metastases. The majority of metastases of TNBC are diagnosed within three years after initial breast cancer diagnosis. While there have been major advances in hormone-receptor- positive and in human epidermal growth factor receptor 2 (HER2)-positive disease over the past two decades, only limited improvements in outcomes for patients with triple negative breast cancer (TNBC) have been observed. A group of Austrian breast cancer specialists therefore convened an expert meeting to establish a comprehensive clinical risk-benefit profile of available mTNBC therapies and discuss the role sacituzumab govitecan may play in the treatment algorithm of the triple-negative breast cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Triple Negative Breast Neoplasms - genetics, drug therapy, therapy, pathology
- Humans - administration & dosage
- Austria - administration & dosage
- Female - administration & dosage
- Algorithms - administration & dosage
- Treatment Outcome - administration & dosage
- Evidence-Based Medicine - administration & dosage
- Find related publications in this database (Keywords)
- Sacituzumab govitecan
- Metastatic breast cancer
- TNBC
- Triple-negative breast cancer