Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Makara, JK; Mor, M; Fegley, D; Szabó, SI; Kathuria, S; Astarita, G; Duranti, A; Tontini, A; Tarzia, G; Rivara, S; Freund, TF; Piomelli, D.
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus.
Nat Neurosci. 2005; 8(9): 1139-41.
Doi: 10.1038/nn1521
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- Co-authors Med Uni Graz
- Szabo Szilard
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- Abstract:
- The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that two previously unknown inhibitors of monoacylglycerol lipase, a presynaptic enzyme that hydrolyzes 2-AG, increase 2-AG levels and enhance retrograde signaling from pyramidal neurons to GABAergic terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and point to monoacylglycerol lipase as a possible drug target.
- Find related publications in this database (using NLM MeSH Indexing)
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