Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szabo, SI; Zelles, T; Lendvai, B.
Intracellular Ca2+ dynamics of hippocampal interneurons following nicotinic acetylcholine receptor activation.
Neurochem Int. 2008; 52(1-2): 135-41.
Doi: 10.1016/j.neuint.2007.05.012
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Szabo Szilard
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- Abstract:
- Ca2+ permeability of central nicotinic acetylcholine receptors (nAChRs), especially the alpha7 subunits, are exceptionally high and this important feature provide a special functional importance for these receptors at the system level. Although studies at the cellular level extensively characterized the molecular properties of Ca2+ influx following nAChR activation, much less is known about the time-related Ca2+ dynamics during nicotine administration in integration units of neurons. Such studies are of particular relevance to understanding in situ nonsynaptic actions of nicotine. Puff ejection of drugs produce a rapid drug delivery and elimination from the cell surface allowing the activation of extrasynaptic receptors within desensitization time-frame. In this report we provide evidence that rapid nicotine application is able to produce irregular Ca2+ transients in the dendrites of stratum radiatum interneurons in the hippocampal CA1 region. Potential components and mechanisms of nAChR-mediated Ca2+ influx are discussed in details to demonstrate the unique feature of activation of nAChRs involved in nonsynaptic function in interneurons as compared to other types of nicotinic activity.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Calcium - metabolism
- Hippocampus - metabolism
- Interneurons - metabolism
- Nicotine - administration & dosage
- Rats - administration & dosage
- Rats, Wistar - administration & dosage
- Receptors, Nicotinic - drug effects
- Find related publications in this database (Keywords)
- nicotinic
- two-photon
- imaging
- calcium
- action potential