Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weiland, T; Gellner, V; Pondorfer, P; Hortobagyi, D; Maitz, E; Kiss, P; Borenich, A; Reininghaus, EZ; Thurnher, D; Tomazic, PV.
Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life.
Eur Arch Otorhinolaryngol. 2024; 281(1):245-256
Doi: 10.1007/s00405-023-08203-6
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- Führende Autor*innen der Med Uni Graz
- Weiland Thomas
- Co-Autor*innen der Med Uni Graz
- Borenich Andrea
- Gellner Verena
- Hortobagyi David
- Kiss Peter
- Maitz Emanuel
- Pondorfer-Schäfer Prisca
- Reininghaus Eva
- Thurnher Dietmar
- Tomazic Peter Valentin
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- Abstract:
- PURPOSE: The aim of this prospective longitudinal study was to assess both subjective quality of life using questionnaires and objective examination of nasal function with regard to olfaction, nasal air flow and mucociliary clearance in patients after minimally invasive, turbinate-preserving endoscopic transnasal trans-sphenoidal pituitary surgery. METHODS: Patients undergoing endoscopic transnasal pituitary surgery were recruited prospectively and examined during three study visits, preoperatively and 3 and 6 months postoperatively. We examined nasal function using sniffin' sticks test, rhinomanometry, saccharin transit time test, and endoscopic and radiological scores. In addition, the influence on subjective quality of life and mental health was recorded using the Sinonasal-Outcome-Test-20 (SNOT-20) and the Hospital-Anxiety-and-Depression-Scale (HADS). RESULTS: 20 patients undergoing endoscopic pituitary tumor resections were included. No significant changes in olfaction or mucociliary clearance were noted. Nasal air flow showed a tendency to increase in the postoperative course lacking significance. Both the endoscopy and the radiological scores showed a significant deterioration, especially after 3 months, with a trend towards improvement over time. However, neither the SNOT-20 nor the HADS showed significant changes compared to baseline. CONCLUSIONS: Our concept of minimally invasive endoscopic tumor resections on the pituitary gland with preservation of nasal turbinates shows low morbidity for the patient. Despite objectifiable surgery-associated changes in the nose, nasal physiology in terms of smell, airflow and mucociliary clearance can be preserved and the subjective quality of life of our patients remains stable.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Quality of Life - administration & dosage
- Prospective Studies - administration & dosage
- Longitudinal Studies - administration & dosage
- Pituitary Neoplasms - surgery
- Treatment Outcome - administration & dosage
- Endoscopy - administration & dosage
- Pituitary Gland - surgery
- Pituitary Diseases - administration & dosage
- Turbinates - surgery
- Find related publications in this database (Keywords)
- Anterior skull base
- Endoscopic minimally invasive surgery of the skull base
- Endoscopic endonasal approach to the pituitary
- Quality of life
- Patient reported outcome measure