Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Grasser, B; Iberer, F; Schaffellner, S; Kniepeiss, D; Schreier, G; Kastner, P; Tscheliessnigg, KH.
Non-invasive graft monitoring after heart transplantation: rationale to reduce the number of endomyocardial biopsies.
Transpl Int. 2000; 13 Suppl 1(2): S225-S227.
Doi: 10.1111/j.1432-2277.2000.tb02024.x
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Iberer Florian
- Kniepeiss Daniela
- Schaffellner Silvia
- Tscheliessnigg Karlheinz
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The endomyocardial biopsy is invasive, reduces quality of life and cannot be repeated daily. Initial studies on noninvasive cardiac graft monitoring have been presented recently. During the heart transplant procedure, we implanted wideband telemetric pacemakers and fractally coated, epimyocardial electrodes. On biopsy days and during each follow-up, intramyocardial electrogram sequences were obtained. The maximum T-slew rate from the ventricular evoked response (VER) was automatically calculated and compared to the biopsy results (n = 331, ISHLT grading). The VER T-slew rate was significantly lower during rejection grade 2 or higher. The negative predictive value to exclude rejection was 98%. Using a single threshold diagnosis model, 74% of the biopsies could have been avoided. Noninvasive cardiac graft monitoring can reduce the need for surveillance biopsies and may offer a tool to optimize immunosuppressive therapy after heart transplantation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Biopsy -
- Electroencephalography -
- Graft Rejection - diagnosis
- Heart Transplantation - methods
- Humans - methods
- Middle Aged - methods
- Pacemaker, Artificial - methods
- Telemetry - methods