Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wertenauer, C; Pfeifer, C; Roskos, M; Marz, W.
Rapid antigen tests for SARS-CoV-2-a synopsis of the medical evidence
DIAGN MICR INFEC DIS. 2023; 107(2): 116027
Doi: 10.1016/j.diagmicrobio.2023.116027
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- SARS-CoV-2, the causative agent of the COVID-19 pandemic, continues to influence health, economy, and stability worldwide. Diagnostic testing for SARS-CoV-2 is important to contain the COVID-19 pandemic. With the commercial availability of certified antigen (Ag) rapid diagnostic tests (RDTs), which can be used to identify an infection with SARS-CoV-2 an easy-to-use tool was introduced. Self-tests can offer advantages to complement professionally administered rapid antigen detection or nucleic acid amplification testing (NAAT). Compared to real-time polymerase chain reaction (RT-PCR), Ag-RDTs are cost inexpensive, do not need specialized laboratory equipment, facilitating high-throughput testing. However, Ag-RDT sensitivities are strongly dependent on the viral load within the specimen, which has limited their application in clinical settings so far. The methodical limitations of Ag-RDTs may produce false negative test results, particularly when specimens with low viral loads are examined. This may facilitate viral transmissions if protective measurements are lifted mistakenly.& COPY; 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- Find related publications in this database (Keywords)
- RDT
- Rapid diagnostic test
- COVID-19
- SARS-CoV-2
- Antigen test
- Rapid antigen detection test