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SHR Neuro Cancer Cardio Lipid Metab Microb
Donyaei, A; Kiani, E; Bahrololoum, H; Moser, O.
Effect of combined aerobic-resistance training and subsequent detraining on brain-derived neurotrophic factor (BDNF) and depression in women with type 2 diabetes mellitus: A randomized controlled trial
DIABETIC MED. 2023; e15188
Doi: 10.1111/dme.15188
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Moser Othmar
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- Abstract:
- Aims: In this study, we assessed the effects of a 12-week combined aerobic-resistance training and subsequent detraining on Beck Depression Inventory (BDI) score and mediating role of BDNF and also investigated whether exercise-induced alterations are maintained following a short period of detraining in women with type 2 diabetes (T2D). Materials and Methods: Thirty-four women with T2D were randomly assigned to experimental or control group (age: 60.6 +/- 6.3, body mass index (BMI): 30.2 +/- 1.3 kg/m(2), HbA1c: 8.09 +/- 0.73%). The exercise training comprised of combined aerobic-resistance programme (50%-70% heart rate reserve for aerobic exercise, and 50%-70% 1 repetition maximum for resistance exercise, respectively) performed three sessions per week over 12 weeks. The intervention period was followed by an 8-week detraining period. Data were collected at baseline and also following exercise intervention and detraining. Data were analysed by linear mixed model at p < 0.05. Results: After 12 weeks of combined exercise training and 8 weeks of detraining, there was a significant difference in BDNF (0.08; 95% confidence interval [CI] = 0.07-0.10; p = 0.001), fasting blood glucose (FBG) (-45.41; CI = -50.83, -39.98; p = 0.001), insulin (-6.47; CI = -7.04, -5.9; p = 0.001), HOMA-IR (-3.76; CI = -4.07, -3.45; p = 0.001) and BDI score (-17.17; CI = -20.29, -14.05; p = 0.001) between the experimental and control group. Multiple mediation analysis indicated that BDNF seems to have a mediating role in exercise-induced improvement of depression (p = 0.04). After the detraining period, BDI score remained unchanged and it showed a significant increase compared to before the start of training (p = 0.001). Conclusions: It may be concluded that exercise training improves depression that is likely to be explained by increased BDNF concentration in TD2. In spite of decreased BDNF concentration following an 8-week detraining, depression score was maintained.
- Find related publications in this database (Keywords)
- BDNF
- depression
- detraining
- diabetes
- exercise