Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Blesl, A; Borenich, A; Gröchenig, HP; Novacek, G; Primas, C; Reinisch, W; Kutschera, M; Illiasch, C; Hennlich, B; Steiner, P; Koch, R; Tillinger, W; Haas, T; Reicht, G; Mayer, A; Ludwiczek, O; Miehsler, W; Steidl, K; Binder, L; Baumann-Durchschein, F; Fürst, S; Reider, S; Watschinger, C; Wenzl, H; Moschen, A; Berghold, A; Högenauer, C, , Austrian, IBD, Study, Group, (ATISG).
Factors Associated with Response to Systemic Corticosteroids in Active Ulcerative Colitis: Results from a Prospective, Multicenter Trial.
J Clin Med. 2023; 12(14):
Doi: 10.3390/jcm12144853
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- Führende Autor*innen der Med Uni Graz
- Blesl Andreas
- Hoegenauer Christoph
- Co-Autor*innen der Med Uni Graz
- Baumann-Durchschein Franziska
- Berghold Andrea
- Binder Lukas
- Borenich Andrea
- Fürst Stefan
- Wenzl Heimo
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- Abstract:
- BACKGROUND: Among patients with ulcerative colitis, 30-50% receive corticosteroids within the first five years after diagnosis. We aimed to reconsider their effectiveness in the context of the biologic era. METHODS: In this prospective, multicenter study, patients with active ulcerative colitis (Lichtiger score ≥ 4) were eligible if initiating systemic corticosteroids. The primary endpoint was clinical response (decrease in the Lichtiger score of ≥50%) at week 4. Secondary endpoints included combined response defined as clinical response and any reduction in elevated biomarkers (CRP and/or calprotectin). Steroid dependence was assessed after three months. RESULTS: A total of 103 patients were included. Clinical response was achieved by 73% of patients, and combined response by 68%. A total of 15% of patients were steroid-dependent. Activity of colitis did not influence short-term response to treatment but increased the risk for steroid dependence. Biologic-naïve patients responded better than biologic-experienced patients. Past smoking history (OR 5.38 [1.71, 20.1], p = 0.003), hemoglobin levels (OR 0.76 [0.57, 0.99] for higher levels, p = 0.045), and biologic experience (OR 3.30 [1.08, 10.6], p = 0.036) were independently associated with nonresponse. CONCLUSION: Disease activity was not associated with short-term response to systemic corticosteroids but was associated with steroid dependence in patients with active ulcerative colitis. Exposure to biologics negatively affects response rates.
- Find related publications in this database (Keywords)
- ulcerative colitis
- systemic corticosteroids
- inflammatory bowel disease