Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Barletta, F; Tappero, S; Morra, S; Incesu, RB; Cano, Garcia, C; Piccinelli, ML; Scheipner, L; Baudo, A; Tian, Z; Gandaglia, G; Stabile, A; Mazzone, E; Terrone, C; Longo, N; Tilki, D; Chun, FKH; de, Cobelli, O; Ahyai, S; Carmignani, L; Saad, F; Shariat, SF; Montorsi, F; Briganti, A; Karakiewicz, PI.
Cancer-Specific Mortality Differences in Specimen-Confined Radical Prostatectomy Patients According to Lymph Node Invasion.
Clin Genitourin Cancer. 2023; Doi: 10.1016/j.clgc.2023.05.010
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Ahyai Sascha; Scheipner Lukas
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Abstract:: PURPOSE: To test cancer-specific mortality (CSM) differences in specimen-confined (pT2) prostate cancer (PCa) at radical prostatectomy (RP) with lymph node dissection (LND) according to lymph node invasion (LNI). METHODS: RP + LND pT2 PCa patients were identified (surveillance, epidemiology, and end results 2010-2015). CSM-FS rates were tested in Kaplan-Meier plots and multivariable Cox-regression (MCR) models. Sensitivity analyses respectively addressing patients with 6 or more lymph nodes analyzed and pT2 pN1 patients were performed. RESULTS: Overall, 32,258 patients with pT2 PCa at RP + LND were identified. Of these, 448 (1.4%) patients harbored LNI. Five-year CSM-free estimates were 99.6% for pN0 vs. 96.4% for pN1 (P < .001). In MCR models, pN1 (HR: 3.4, P < .001) independently predicted higher CSM. In sensitivity analyses addressing patients with 6 or more lymph nodes analyzed (n = 15,437), 328 (2.1%) pN1 patients were identified. In this subgroup, 5-year CSM-free estimates were 99.6% for pN0 vs. 96.3% for pN1 (P < .001) and, in MCR models, pN1 independently predicted higher CSM (HR: 4.4, P < .001). In sensitivity analyses addressing pT2 pN1 patients, 5-year CSM-free estimates were 99.3, 100 and 84.8% for ISUP GG 1-3 vs. 4 vs. 5, respectively (P < .001). CONCLUSIONS: In patients with pT2 PCa a small proportion harbor LNI (1.4%-2.1%). In such patients, CSM rate is higher (HR 3.4-4.4, P < .001). This higher CSM risk seems to virtually exclusively apply to ISUP GG5 patients (84.8% 5-year CSM-free rate).
Find related publications in this database (Keywords): SEER program; Prostate cancer; Organ confined