Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Scheipner, L; Cano, Garcia, C; Barletta, F; Incesu, RB; Morra, S; Baudo, A; Assad, A; Tian, Z; Saad, F; Shariat, SF; Chun, FKH; Briganti, A; Tilki, D; Longo, N; Carmignani, L; Leitsmann, M; Ahyai, S; Karakiewicz, PI.
Regional differences in penile cancer patient characteristics and treatment rates across the United States.
Cancer Epidemiol. 2023; 86:102424
Doi: 10.1016/j.canep.2023.102424
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Scheipner Lukas
- Co-Autor*innen der Med Uni Graz
- Ahyai Sascha
- Leitsmann Marianne
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- Abstract:
- INTRODUCTION: We tested for regional-specific differences in patient, tumor and treatment characteristics as well as cancer-specific mortality (CSM) of squamous cell carcinoma of the penis (SCCP) patients, across the Surveillance, Epidemiology, and End Results (SEER) registries. METHODS: The SEER database (2000-2018) was used to tabulate patient (age at diagnosis, race/ethnicity), tumor (stage, grade, N-stage) and treatment characteristics (proportions of primary tumor surgery, local lymph node surgery, systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models tested for CSM differences, adjusting for patient, tumor and treatment characteristics. RESULTS: In 5395 SCCP patients, registry-specific patient counts ranged from 2060 (38 %) to 64 (1 %). Differences across registries existed for race/ethnicity, stage, grade and N-stage. Additionally, in stage I-II SCCP patients, proportions of local tumor destruction (LTD) ranged from 19 % to 39 % and from 33 % to 61 % for partial penectomy. In stage III-IV SCCP patients, proportions of partial penectomy ranged from 40 % to 59 % and from 17 % to 50 % for radical penectomy. Local lymph node surgery ranged from 8 % to 24 % and proportions of systemic therapy ranged from 3 % to 14 %. Significant inter-registry differences remained, after adjustment for treatment proportions. Unadjusted five-year CSM ranged from 19 % to 32 %. In multivariable analyses, one registry exhibited significantly higher CSM (SEER registry 10, Hazard Ratio [HR] 1.48), relative to the largest reference registry (SEER registry 1, n = 2060). CONCLUSION: Important regional differences including patient, tumor and treatment characteristics exist for SCCP patients across SEER registries. After multivariable adjustment, no differences in CSM were recorded, with the exception of one registry.
- Find related publications in this database (using NLM MeSH Indexing)
- Male - administration & dosage
- Humans - administration & dosage
- United States - epidemiology
- Penile Neoplasms - epidemiology, therapy
- SEER Program - administration & dosage
- Lymph Nodes - pathology
- Proportional Hazards Models - administration & dosage
- Carcinoma, Squamous Cell - epidemiology, therapy
- Find related publications in this database (Keywords)
- Penile cancer
- SEER
- CSM
- Region
- Heterogeneity