Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Köppel, H; Renner, W; Krippl, P; Wascher, TC; Pilger, E.
Diminished response to activated protein C is not correlated with severity of peripheral arterial occlusive disease.
Clin Lab. 2004; 50(11-12): 689-693.
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- Co-Autor*innen der Med Uni Graz
- Krippl Peter
- Pilger Ernst
- Renner Wilfried
- Wascher Thomas
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- Abstract:
- INTRODUCTION: Poor response to activated Protein C (APC) is a well established risk factor for venous thromboembolism. More recently, the hypercoagulable state which results from diminished response to APC has also been associated with arterial thrombosis. Some studies showed a clear association between low response to APC with advanced arterial disease, others, however, failed to support these data. Thus, there is ongoing dispute about the impact of a hypercoagulable state upon progression of atherosclerosis. MATERIAL AND METHODS: We investigated APC ratios and the existence of Factor V Leiden in 800 patients with documented peripheral arterial occlusive disease (PAD). Clinical symptoms according to Fontaine stages II (intermittent claudication), III (rest pain) and IV (gangrene) and the ankle/brachial index served as parameters for the severity of PAD. RESULTS: There was no association between low response to APC or existence of Factor V Leiden and the clinical stage of PAD or ankle/ brachial index. CONCLUSION: Our data suggest that poor response to APC is not correlated with the severity of peripheral arterial occlusive disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Activated Protein C Resistance - complications
- Aged - complications
- Arterial Occlusive Diseases - classification
- Arteriosclerosis - etiology
- Factor V - genetics
- Female - genetics
- Genotype - genetics
- Heterozygote - genetics
- Humans - genetics
- Male - genetics
- Middle Aged - genetics
- Protein C - metabolism
- Thrombophilia - complications