Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ruggieri, F; Jonas, K; Ferracin, M; Dengler, M; Jӓger, V; Pichler, M.
MicroRNAs as regulators of tumor metabolism.
Endocr Relat Cancer. 2023; 30(8):
Doi: 10.1530/ERC-22-0267
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Ruggieri Francesca
- Co-Autor*innen der Med Uni Graz
- Dengler Michael
- Jäger Vanessa
- Jonas Katharina
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- Abstract:
- Cancer cells reprogram their metabolism to support their growth. Since the discovery of the Warburg effect, several other metabolic alterations and metabolites have been described in cancer cells, including lactate, glutamine, and lipid metabolism reprogramming. Together these alterations provide rapidly dividing tumor cells with metabolic intermediates needed for nucleotide, protein, and fatty acid biosynthesis. MicroRNAs are a class of small non-coding RNAs involved in the regulation of virtually all biological pathways. Altered microRNA expression patterns are associated with the onset and development of several diseases, including cancer. Tumor suppressor microRNAs targeting molecules involved in tumor metabolism are frequently downregulated in cancers. Therefore, microRNAs can serve as potential tumor biomarkers and also represent interesting therapeutic targets. This review summarizes recent findings about microRNAs involved in the regulation of tumor metabolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- MicroRNAs - genetics, metabolism
- Neoplasms - metabolism
- Genes, Tumor Suppressor - administration & dosage
- Lipid Metabolism - administration & dosage
- Glycolysis - administration & dosage
- Gene Expression Regulation, Neoplastic - administration & dosage
- Find related publications in this database (Keywords)
- tumor metabolism
- microRNAs
- small non-coding RNAs
- cancer