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Embacher, S; Maertens, K; Herzog, SA.
Half-life Estimation of Pertussis-Specific Maternal Antibodies in (Pre)Term Infants After In-Pregnancy Tetanus, Diphtheria, Acellular Pertussis Vaccination
J INFECT DIS. 2023; Doi: 10.1093/infdis/jiad212 [OPEN ACCESS]
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Leading authors Med Uni Graz: Embacher Stefan; Herzog Sereina Annik
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Abstract:: Background To reduce the risk of pertussis-related morbidity and mortality in early life, an increasing number of countries recommend maternal pertussis vaccination. However, there is limited knowledge about half-lives of vaccine-induced pertussis-specific maternal antibodies, especially in preterm infants, and factors potentially influencing them. Methods We compared 2 different approaches to provide estimates of the half-lives of pertussis-specific maternal antibodies in infants and explored potential effects on the half-life in 2 studies. In the first approach, we estimated the half-lives per child and used these estimates as responses in linear models. In the second approach, we used linear mixed effect models on a log(2) transformed scale of the longitudinal data to use the inverse of the time parameter as an estimate for the half-lives. Results Both approaches provided similar results. The identified covariates partly explain differences in half-life estimates. The strongest evidence we observed was a difference between term and preterm infants, with the preterm infants showing a longer half-life. Among others, a longer interval between vaccination and delivery increases the half-life. Conclusions Several variables influence the decay speed of maternal antibodies. Both approaches have advantages and disadvantages, while the choice is secondary when assessing the half-life of pertussis-specific antibodies. We compared 2 approaches for estimating the half-life of vaccine-induced pertussis-specific maternal antibodies, focusing on the difference between preterm and term-born infants, while also examining other variables. Both approaches yielded similar results, with preterm infants showing a higher half-life.
Find related publications in this database (Keywords): antibody kinetic; half-life estimation; maternal antibodies; pertussis; Tdap; vaccination in pregnancy