Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gail, LM; Schell, KJ; Lacina, P; Strobl, J; Bolton, SJ; Ulriksen, ES; Bogunia-Kubik, K; Greinix, H; Crossland, RE; Inngjerdingen, M; Stary, G.
Complex interactions of cellular players in chronic Graft-versus-Host Disease
FRONT IMMUNOL. 2023; 14: 1199422
Doi: 10.3389/fimmu.2023.1199422
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types via extracellular vesicles as up-and-coming fields in chronic Graft-versus-Host Disease research. Lastly, we discuss the importance of understanding systemic and local aberrant cell communication during disease for defining better biomarkers and therapeutic targets, eventually enabling the design of personalized treatment schemes.
- Find related publications in this database (Keywords)
- chronic graft-versus-host disease
- hematopoietic stem cell transplantation
- immune cell networks
- cell-cell communication
- GvHD pathogenesis