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Kupsa, R; Gruber-Wackernagel, A; Hofer, A; Quehenberger, F; Wolf, P; Legat, FJ.
Narrowband-ultraviolet B vs Broadband-ultraviolet B in Treatment of Chronic Pruritus: A Randomized, Single-blinded, Non-inferiority Study.
ACTA DERM-VENEREOL. 2023; 103: adv9403 Doi: 10.2340/actadv.v103.9403 [OPEN ACCESS]
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Leading authors Med Uni Graz: Kupsa Romana; Legat Franz
Co-authors Med Uni Graz: Gruber-Wackernagel Alexandra; Hofer Angelika; Quehenberger Franz; Wolf Peter
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Abstract:: Narrowband-ultraviolet B has shown increased efficacy over broadband-ultraviolet B in pruritic skin diseases, such as psoriasis and atopic dermatitis. In patients with chronic pruritus, e.g. in end-stage renal disease, broadband-ultraviolet B is recommended, but narrowband-ultraviolet B has also shown efficacy in reducing pruritus. This randomized, single blinded, non-inferiority study investigated the effects of narrowband-ultraviolet B compared with broadband-ultraviolet B. Patients with chronic pruritus were treated with either broadband- or narrowband-UVB 3 times a week for 6 weeks and clinical response was monitored. Pruritus, sleep disturbance, and the patients' subjective overall response to treatment were evaluated by the patients on a visual analogue scale (0-10). Skin excoriations were evaluated by investigators on a 4-point scale (0-3). Both phototherapeutic modalities showed significant antipruritic activity (itch reduction 48% and 66.4%, respectively) by broadband-ultraviolet B and narrowband-ultraviolet B. Narrowband-ultraviolet B proved to be not inferior to broadband-ultraviolet B in treating pruritus in patients with chronic pruritus, assuming a 20% non-inferiority margin.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Ultraviolet Therapy - adverse effects; Pruritus - diagnosis, drug therapy, etiology; Psoriasis - therapy; Dermatitis, Atopic - diagnosis, radiotherapy, etiology; Data Collection - administration & dosage; Treatment Outcome - administration & dosage
Find related publications in this database (Keywords): chronic pruritus; itch; prurigo; phototherapy