Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stimmeder, S; Leber, B; Sucher, R; Stiegler, P.
Genetic Modulation: Future Trends Toward Graft Optimization During Machine Perfusion.
Transplantation. 2024; 108(3):614-624
Doi: 10.1097/TP.0000000000004738
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- Führende Autor*innen der Med Uni Graz
- Leber Bettina
- Stimmeder Sabrina
- Co-Autor*innen der Med Uni Graz
- Stiegler Philipp
- Sucher Robert
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- Abstract:
- Dynamic preservation methods such as normothermic, subnormothermic, and hypothermic machine perfusion circuits have emerged as viable alternatives to conventional static cold storage. These organ perfusion technologies serve as preservation methods and enable organ assessment, reconditioning, and repair before transplantation. Gene therapy is a novel strategy with the potential to transform the field of graft optimization and treatment. Thereby specific pathways involved in the transplantation process can be targeted and modified. This review aims to provide an overview of gene delivery methods during ex vivo machine perfusion of kidney and liver grafts. Recent literature on state-of-the-art gene therapy approaches during ex situ organ preservation, especially with respect to ischemia-reperfusion injury, as well as acute and chronic graft rejection have been analyzed. Additionally, potential challenges that could affect further refinement of this therapeutic modality are outlined.
- Find related publications in this database (using NLM MeSH Indexing)
- Perfusion - adverse effects, methods
- Kidney - administration & dosage
- Organ Preservation - methods
- Kidney Transplantation - methods
- Extracorporeal Circulation - administration & dosage