Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ascani, A; Torstensson, S; Risal, S; Lu, H; Eriksson, G; Li, C; Teschl, S; Menezes, J; Sandor, K; Ohlsson, C; Svensson, CI; Karlsson, MCI; Stradner, MH; Obermayer-Pietsch, B; Stener-Victorin, E.
The role of B cells in immune cell activation in polycystic ovary syndrome.
Elife. 2023; 12:
Doi: 10.7554/eLife.86454
[OPEN ACCESS]
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Ascani Angelo
- Obermayer-Pietsch Barbara
- Co-Autor*innen der Med Uni Graz
- Stradner Martin Helmut
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- Abstract:
- Variations in B cell numbers are associated with polycystic ovary syndrome (PCOS) through unknown mechanisms. Here, we demonstrate that B cells are not central mediators of PCOS pathology and that their frequencies are altered as a direct effect of androgen receptor activation. Hyperandrogenic women with PCOS have increased frequencies of age-associated double-negative B memory cells and increased levels of circulating immunoglobulin M (IgM). However, the transfer of serum IgG from women into wild-type female mice induces only an increase in body weight. Furthermore, RAG1 knockout mice, which lack mature T- and B cells, fail to develop any PCOS-like phenotype. In wild-type mice, co-treatment with flutamide, an androgen receptor antagonist, prevents not only the development of a PCOS-like phenotype but also alterations of B cell frequencies induced by dihydrotestosterone (DHT). Finally, B cell-deficient mice, when exposed to DHT, are not protected from developing a PCOS-like phenotype. These results urge further studies on B cell functions and their effects on autoimmune comorbidities highly prevalent among women with PCOS.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Mice - administration & dosage
- Animals - administration & dosage
- Polycystic Ovary Syndrome - genetics, pathology
- Androgens - administration & dosage
- Body Weight - administration & dosage
- Phenotype - administration & dosage
- Find related publications in this database (Keywords)
- polycystic ovary syndrome
- androgens
- B cells
- immune