Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Foessl, I; Dimai, HP; Obermayer-Pietsch, B.
Long-term and sequential treatment for osteoporosis.
Nat Rev Endocrinol. 2023; 19(9):520-533
Doi: 10.1038/s41574-023-00866-9
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Fößl Ines
- Obermayer-Pietsch Barbara
- Co-Autor*innen der Med Uni Graz
- Dimai Hans Peter
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- Abstract:
- Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength, leading to a progressively increased risk of fragility fractures. The global prevalence of osteoporosis is increasing in the ageing population. Owing to the chronic character of osteoporosis, years or even decades of preventive measures or therapy are required. The long-term use of bone-specific pharmacological treatment options, including antiresorptive and/or osteoanabolic approaches, has raised concerns around adverse effects or potential rebound phenomena after treatment discontinuation. Imaging options, risk scores and the assessment of bone turnover during initiation and monitoring of such therapies could help to inform individualized treatment strategies. Combination therapies are currently used less often than 'sequential' treatments. However, all patients with osteoporosis, including those with secondary and rare causes of osteoporosis, as well as specific patient populations (for example, young adults, men and pregnant women) require new approaches for long-term therapy and disease monitoring. New pathophysiological aspects of bone metabolism might therefore help to inform and revolutionize the diagnosis and treatment of osteoporosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Male - administration & dosage
- Humans - administration & dosage
- Female - administration & dosage
- Pregnancy - administration & dosage
- Bone Density Conservation Agents - therapeutic use
- Osteoporosis - diagnosis, drug therapy
- Fractures, Bone - prevention & control
- Risk Factors - administration & dosage
- Bone Density - administration & dosage