Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Malanovic, N; Vejzovic, D.
Novel insights at the crossroads of antibiotic use and cancer risk
CELL STRESS. 2023; 7(6): 46-49.
Doi: 10.15698/cst2023.06.280
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- Co-Autor*innen der Med Uni Graz
- Vejzovic Djenana
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- Abstract:
- The continuous use of antibiotics is associated with the spread of antimicrobial resistances and the not yet clear link to cancer development. Many conventional antibiotics have already shown different effects on a variety of cancer types raising questions for their ra- tional use in cancer. However, discrepancy in the ob- served trend for some antibiotics reducing cancer de- velopment and being associated with higher risk of cancer underscores the lack of understanding the complex link between antibiotics and cancer. Here, we briefly summarize the possible antibiotic-mediated effects on cancer and conclude that those effects can be direct via i) specific targeting of tumor/cancer, ii) antimicrobial activity and iii) immunomodulatory activ- ity whereby iv) indirectly caused effects primarily af- fect immune equilibrium between bacteria, cancer and immune cells. Furthermore, we also conclude that there is a great need for bulk profiling, comprehensive screening programs in all countries and in-depth stud- ies to understand the risks and benefits of antibiotic use.