Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lajin, B; Obermayer-Pietsch, B; Somma, R; Goessler, W.
A time-course investigation of the human urinary excretion of the hydrogen sulfide biomarker trimethylsulfonium
ENVIRON TOXICOL PHAR. 2023; 100: 104162
Doi: 10.1016/j.etap.2023.104162
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Lajin Bassam
- Co-Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
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- Abstract:
- Hydrogen sulfide is a toxic gas but also recognized as an endogenously produced metabolite in humans playing key roles. We previously identified trimethylsulfonium, which can be a methylation product of hydrogen sulfide but the stability in the production of trimethylsulfonium has not been investigated. In the present work, the intra-and inter-individual variability in the excretion of trimethylsulfonium over 2 months in a group of healthy volunteers was investigated. Urinary levels of trimethylsulfonium (mean: 56 nM, 95% CI: 48-68 nM) were > 100-fold lower than the conventional hydrogen sulfide biomarker thiosulfate (13 mu M, 12-15 mu M) and the pre-cursor for endogenous hydrogen sulfide production cystine (47 mu M, 44-50 mu M). There was no correlation be-tween urinary trimethylsulfonium and thiosulfate. Higher intra-individual variability in the excretion of trimethylsulfonium (generally 2-8 fold) than that for cystine (generally 2-3 fold) was found. Trimethylsulfonium displayed significant inter-individual variability with two concentration clusters at 117 nM (97-141) and 27 nM (22-34). In conclusion, the observed inter-and intra-individual variability must be considered when using urinary trimethylsulfonium as a biomarker.
- Find related publications in this database (Keywords)
- Trimethylsulfonium
- Hydrogen sulfide
- Thiosulfate
- Third gasotransmitter