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Bauer, M; Glenn, T; Achtyes, ED; Alda, M; Agaoglu, E; Altınbaş, K; Andreassen, OA; Angelopoulos, E; Ardau, R; Aydin, M; Ayhan, Y; Baethge, C; Bauer, R; Baune, BT; Balaban, C; Becerra-Palars, C; Behere, AP; Behere, PB; Belete, H; Belete, T; Belizario, GO; Bellivier, F; Belmaker, RH; Benedetti, F; Berk, M; Bersudsky, Y; Bicakci, Ş; Birabwa-Oketcho, H; Bjella, TD; Brady, C; Cabrera, J; Cappucciati, M; Castro, AMP; Chen, WL; Cheung, EYW; Chiesa, S; Crowe, M; Cuomo, A; Dallaspezia, S; Del, Zompo, M; Desai, P; Dodd, S; Etain, B; Fagiolini, A; Fellendorf, FT; Ferensztajn-Rochowiak, E; Fiedorowicz, JG; Fountoulakis, KN; Frye, MA; Geoffroy, PA; Gitlin, MJ; Gonzalez-Pinto, A; Gottlieb, JF; Grof, P; Haarman, BCM; Harima, H; Hasse-Sousa, M; Henry, C; Hoffding, L; Houenou, J; Imbesi, M; Isometsä, ET; Ivkovic, M; Janno, S; Johnsen, S; Kapczinski, F; Karakatsoulis, GN; Kardell, M; Kessing, LV; Kim, SJ; König, B; Kot, TL; Koval, M; Kunz, M; Lafer, B; Landén, M; Larsen, ER; Lenger, M; Licht, RW; Lopez-Jaramillo, C; MacKenzie, A; Madsen, HØ; Madsen, SAKA; Mahadevan, J; Mahardika, A; Manchia, M; Marsh, W; Martinez-Cengotitabengoa, M; Martini, J; Martiny, K; Mashima, Y; McLoughlin, DM; Meesters, Y; Melle, I; Meza-Urzúa, F; Mikolas, P; Mok, YM; Monteith, S; Moorthy, M; Morken, G; Mosca, E; Mozzhegorov, AA; Munoz, R; Mythri, SV; Nacef, F; Nadella, RK; Nakanotani, T; Nielsen, RE; O'Donovan, C; Omrani, A; Osher, Y; Ouali, U; Pantovic-Stefanovic, M; Pariwatcharakul, P; Petite, J; Petzold, J; Pfennig, A; Ruiz, YP; Pinna, M; Pompili, M; Porter, RJ; Quiroz, D; Rabelo-da-Ponte, FD; Ramesar, R; Rasgon, N; Ratta-Apha, W; Ratzenhofer, M; Redahan, M; Reddy, MS; Reif, A; Reininghaus, EZ; Richards, JG; Ritter, P; Rybakowski, JK; Sathyaputri, L; Scippa, AM; Simhandl, C; Smith, D; Smith, J; Stackhouse, PW; Stein, DJ; Stilwell, K; Strejilevich, S; Su, KP; Subramaniam, M; Sulaiman, AH; Suominen, K; Tanra, AJ; Tatebayashi, Y; Teh, WL; Tondo, L; Torrent, C; Tuinstra, D; Uchida, T; Vaaler, AE; Vieta, E; Viswanath, B; Yoldi-Negrete, M; Yalcinkaya, OK; Young, AH; Zgueb, Y; Whybrow, PC.
Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder.
Int J Bipolar Disord. 2023; 11(1): 22
Doi: 10.1186/s40345-023-00303-w
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- Co-authors Med Uni Graz
- Fellendorf Frederike
- Lenger Melanie
- Reininghaus Eva
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- Abstract:
- BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample. METHODS: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001. RESULTS: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger. CONCLUSION: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.