Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Alwan, H; Ware, J; Boughton, CK; Wilinska, ME; Allen, JM; Lakshman, R; Nwokolo, M; Hartnell, S; Bally, L; de, Beaufort, C; Besser, REJ; Campbell, FM; Davis, N; Denvir, L; Evans, ML; Fröhlich-Reiterer, E; Ghatak, A; Hofer, SE; Kapellen, TM; Leelarathna, L; Mader, JK; Narendran, P; Rami-Mehrar, B; Tauschmann, M; Thabit, H; Thankamony, A; Hovorka, R.
Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery.
Diabetes Technol Ther. 2023; 25(7):485-491
Doi: 10.1089/dia.2023.0061
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Fröhlich-Reiterer Elke
- Mader Julia
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- Abstract:
- Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2-7 years), children and adolescents (8-18 years), adults (19-59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia <3.9 mmol/L (<70 mg/dL). Eight weeks of data for 88 participants were analyzed. Results: Median time spent in hypoglycemia over the 24-h period was highest in children and adolescents (4.4% [interquartile range 2.4-5.0]) and very young children (4.0% [3.4-5.2]), followed by adults (2.7% [1.7-4.0]), and older adults (1.8% [1.2-2.2]); P < 0.001 for difference between age groups. Time spent in hypoglycemia during nighttime (midnight-05:59) was lower than during daytime (06:00-23:59) across all age groups. Conclusion: Time in hypoglycemia was highest in the pediatric age group during closed-loop insulin delivery. Hypoglycemia burden was lowest overnight across all age groups.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Aged - administration & dosage
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Humans - administration & dosage
- Blood Glucose - administration & dosage
- Cross-Over Studies - administration & dosage
- Diabetes Mellitus, Type 1 - drug therapy
- Hypoglycemia - chemically induced, drug therapy
- Hypoglycemic Agents - therapeutic use
- Insulin - adverse effects
- Insulin Infusion Systems - administration & dosage
- Insulin, Regular, Human - therapeutic use
- Retrospective Studies - administration & dosage
- Treatment Outcome - administration & dosage
- Young Adult - administration & dosage
- Adult - administration & dosage
- Middle Aged - administration & dosage
- Find related publications in this database (Keywords)
- Type 1 diabetes
- Artificial pancreas
- Closed-loop insulin delivery
- Randomized trial
- Insulin pump therapy