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SHR Neuro Cancer Cardio Lipid Metab Microb

Woelkart, K; Koidl, C; Grisold, A; Gangemi, JD; Turner, RB; Marth, E; Bauer, R.
Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans.
J Clin Pharmacol. 2005; 45(6):683-689 Doi: 10.1177/0091270004273493
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Co-authors Med Uni Graz: Grisold Andrea; Koidl Christoph; Marth Egon
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Abstract:: Alkamides are suspected to contribute to the activity of Echinacea preparations. They are mainly derived from undeca- and dodecanoic acid and differ in the degree of unsaturation and the configuration of the double bonds. In total, 6 alkamides have been isolated from the roots of Echinacea angustifolia as major lipophilic constituents and have been investigated regarding their pharmacokinetics. A sensitive and specific method has been developed for the identification and quantification of these alkamides in human plasma using liquid chromatography electrospray ionization ion-trap mass spectrometry. The method was applied to analyze plasma samples obtained from a randomized, open, single-dose, crossover study after oral administration of a 60% ethanolic extract from the roots of E. angustifolia to 11 healthy subjects. The maximum concentration of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides, the main alkamides in the roots of E. angustifolia, appeared already after 30 minutes and was 10.88 ng/mL for the 2.5-mL dose.
Find related publications in this database (using NLM MeSH Indexing): Administration, Oral -; Adult -; Amides - administration & dosage Amides - analysis Amides - isolation & purification Amides - pharmacokinetics; Anti-Inflammatory Agents - analysis Anti-Inflammatory Agents - pharmacokinetics; Biological Availability -; Echinacea -; Ethanol - chemistry; Fatty Acids, Unsaturated - administration & dosage Fatty Acids, Unsaturated - analysis Fatty Acids, Unsaturated - pharmacokinetics; Female -; Humans -; Male -; Phytotherapy -; Plant Extracts - blood Plant Extracts - chemistry Plant Extracts - pharmacology; Plant Roots - chemistry; Polyunsaturated Alkamides -
Find related publications in this database (Keywords): Echinacea angustifolia; alkamides; bioavailability; pharmacokinetics