Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gottschalk, B; Malli, R; Graier, WF.
MICU1 deficiency alters mitochondrial morphology and cytochrome C release.
Cell Calcium. 2023; 113:102765
Doi: 10.1016/j.ceca.2023.102765
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Gottschalk Benjamin
- Graier Wolfgang
- Co-Autor*innen der Med Uni Graz
- Malli Roland
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- Abstract:
- The mitochondrial inner boundary membrane harbors a protein called MICU1, which is sensitive to Ca2+ and binds to the MICOS components Mic60 and CHCHD2. Changes in the mitochondrial cristae junction structure and organization in MICU1-/- cells lead to increased cytochrome c release, membrane potential rearrangement, and changes in mitochondrial Ca2+ uptake dynamics. These findings shed new light on the multifaceted role of MICU1, highlighting its involvement not only as an interaction partner and regulator of the MCU complex but also as a crucial determinant of mitochondrial ultrastructure and, thus, an essential player in processes initiating apoptosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Cytochromes c - metabolism
- Mitochondrial Membrane Transport Proteins - metabolism
- Mitochondria - metabolism
- Mitochondrial Membranes - metabolism
- Calcium-Binding Proteins - metabolism
- Find related publications in this database (Keywords)
- Mitochondria
- MICU1
- Cristae junction
- MICOS-complex
- Ca2+ signaling
- Apoptosis