Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cervar, M; Kainer, F; Desoye, G.
Pre-eclampsia and gestational age differently alter binding of endothelin-1 to placental and trophoblast membrane preparations.
Mol Cell Endocrinol. 1995; 110(1-2):65-71
Doi: 10.1016%2F0303-7207%2895%2903517-B
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- Führende Autor*innen der Med Uni Graz
- Cervar-Zivkovic Mila
- Co-Autor*innen der Med Uni Graz
- Desoye Gernot
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- Abstract:
- The aim of the study was to compare the binding of endothelin-1 (ET-1) to membranes from placental tissue and trophoblast cells in normal and pre-eclamptic pregnancies. Plasma membranes from placental tissue and trophoblastic cells were prepared from 15 control and 18 pre-eclamptic pregnancies at either preterm (weeks 31-36) or term (weeks 37-40). ET-1 binding to tissue membranes was measured by a radioreceptor assay. In addition, binding of 56 nmol/l [125I]ET-1 to plasma membranes of trophoblastic cells was determined. In pre-eclampsia, placental membranes bound less (P < 0.01) ET-1 owing to fewer (P < 0.01) receptors at preterm than in the corresponding preterm controls. In contrast, binding of [125I]ET-1 to plasma membranes of trophoblast cells was higher (P < 0.01) in pre-eclampsia at both gestational stages than in the controls. Incubation of trophoblast cells with hydralazine reduced binding by 70%. We conclude that pre-eclampsia is associated with changes in the binding of ET-1 to its placental receptors. Moreover, the data suggest that pre-eclampsia affects non-trophoblast cells in the opposite manner to the trophoblast.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cell Membrane - metabolism
- Endothelins - metabolism
- Female - metabolism
- Humans - metabolism
- Hydralazine - pharmacology
- Placenta - metabolism
- Pre-Eclampsia - metabolism
- Pregnancy - metabolism
- Receptors, Endothelin - metabolism
- Time Factors - metabolism
- Trophoblasts - metabolism
- Find related publications in this database (Keywords)
- Preeclampsia
- Placenta
- Trophoblast
- Endothelin-1 Receptors