Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enko, D; Schaflinger, E; Müller, DJ.
[Clinical Application Examples of a Next-Generation Sequencing based Multi-Genepanel Analysis].
Dtsch Med Wochenschr. 2023; 148(11): 695-702.
Doi: 10.1055/a-2033-5329
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Enko Dietmar
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- Abstract:
- This review provides an overview of clinically useful applications of a next-generation sequencing (NGS)-based multi-gene panel testing strategy in the areas of oncology, hereditary tumor syndromes, and hematology. In the case of solid tumors (e.g. lung carcinoma, colon-rectal carcinoma), the detection of somatic mutations contributes not only to a better diagnostic but also therapeutic stratification of those affected. The increasing genetic complexity of hereditary tumor syndromes (e.g. breast and ovarian carcinoma, lynch syndrome/polyposis) requires a multi-gene panel analysis of germline mutations in affected families. Another useful indication for a multi-gene panel diagnostics and prognosis assessment are acute and chronic myeloid diseases. The criteria of the WHO-classification and the European LeukemiaNet-prognosis system for acute myeloid leukemia can only be met by a multi-gene panel test strategy.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Genetic Predisposition to Disease - administration & dosage
- Genetic Testing - administration & dosage
- Germ-Line Mutation - genetics
- Carcinoma - genetics
- High-Throughput Nucleotide Sequencing - administration & dosage
- Mutation - genetics
- Find related publications in this database (Keywords)
- Next-generation sequencing
- targeted sequencing
- oncology
- hereditary tumor syndromes
- hematology