Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lőcsei, Z; Farkas, R; Borbásné, Farkas, K; Sebestyén, K; Sebestyén, Z; Musch, Z; Vojcek, Á; Benedek, N; Mangel, L; Ottóffy, G.
Assessment of the results and hematological side effects of 3D conformal and IMRT/ARC therapies delivered during craniospinal irradiation of childhood tumors with a follow-up period of five years.
BMC Cancer. 2020; 20(1): 702
Doi: 10.1186/s12885-020-07168-7
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Löcsei Zoltan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: Craniospinal irradiation (CSI) of childhood tumors with the RapidArc technique is a new method of treatment. Our objective was to compare the acute hematological toxicity pattern during 3D conformal radiotherapy with the application of the novel technique. METHODS: Data from patients treated between 2007 and 2014 were collected, and seven patients were identified in both treatment groups. After establishing a general linear model, acute blood toxicity results were obtained using SPSS software. Furthermore, the exposure dose of the organs at risk was compared. Patients were followed for a minimum of 5 years, and progression-free survival and overall survival data were assessed. RESULTS: After assessment of the laboratory parameters in the two groups, it may be concluded that no significant differences were detected in terms of the mean dose exposures of the normal tissues or the acute hematological side effects during the IMRT/ARC and 3D conformal treatments. Laboratory parameters decreased significantly compared to the baseline values during the treatment weeks. Nevertheless, no significant differences were detected between the two groups. No remarkable differences were confirmed between the two groups regarding the five-year progression-free survival or overall survival, and no signs of serious organ toxicity due to irradiation were observed during the follow-up period in either of the groups. CONCLUSION: The RapidArc technique can be used safely even in the treatment of childhood tumors, as the extent of the exposure dose in normal tissues and the amount of acute hematological side effects are not higher with this technique.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Analysis of Variance - administration & dosage
- Blood Cells - radiation effects
- Brain Neoplasms - blood, radiotherapy
- Child - administration & dosage
- Child, Preschool - administration & dosage
- Craniospinal Irradiation - adverse effects, methods, mortality
- Follow-Up Studies - administration & dosage
- Humans - administration & dosage
- Liver - radiation effects
- Organs at Risk - radiation effects
- Pelvic Bones - radiation effects
- Progression-Free Survival - administration & dosage
- Radiotherapy Setup Errors - prevention & control
- Radiotherapy, Conformal - adverse effects, methods, mortality
- Radiotherapy, Intensity-Modulated - adverse effects, methods, mortality
- Retrospective Studies - administration & dosage
- Spine - radiation effects
- Spleen - radiation effects
- Sternum - radiation effects
- Time Factors - administration & dosage
- Treatment Outcome - administration & dosage
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- Craniospinal irradiation
- Medulloblastoma
- RapidArc
- Childhood cancer