Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Samonigg, H; Stöger, H; Kasparek, AK; Schmid, M; Dusleag, J; Pfeiffer, K; Smola, M; Steindorfer, P; Lechner, P.
Prednimustine combined with mitoxantrone and 5-fluorouracil for first and second-line chemotherapy in advanced breast cancer.
Cancer Chemother Pharmacol. 1991; 27(6):477-480
Doi: 10.1007/BF00685163
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- Führende Autor*innen der Med Uni Graz
- Samonigg Hellmut
- Co-Autor*innen der Med Uni Graz
- Kasparek Anne-Katrin
- Smola Michael
- Stöger Herbert
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- Abstract:
- A total of 60 patients with advanced breast cancer were treated with a combination of prednimustine (P: 110 mg/m2, days 1-5), mitoxantrone (M: 12 mg/m2, day 1) and 5-fluorouracil (F: 500 mg/m2, day 1) (PMF). Treatment was repeated every 3 weeks. In all 53 patients were evaluable for response. A total of 12 subjects had failed prior chemotherapy for metastatic disease. In response to PMF treatment we observed 21 partial remissions and 3 complete remissions, amounting to a total response rate of 45%. The median duration of response was 39 weeks, and median survival was 56 weeks. Dose-limiting side effects were leukopenia (40 cases) and thrombocytopenia (11 patients). Nausea and vomiting was experienced by 93% of subjects; in 56% of cases it reached WHO stage II-III. Alopecia occurred in 18% of our patients. Our results suggest that PMF represents an active regimen in the treatment of advanced breast cancer and yields a response rate of 45%. Considering that the majority of our patients had not received prior chemotherapy, the question remains open as to whether a 45% response rate outweighs the observed toxicity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - drug therapy
- Breast Neoplasms - mortality
- Chi-Square Distribution -
- Drug Evaluation -
- Female -
- Fluorouracil - administration & dosage
- Fluorouracil - adverse effects
- Humans -
- Leukopenia - chemically induced
- Middle Aged -
- Mitoxantrone - administration & dosage
- Mitoxantrone - adverse effects
- Nausea - chemically induced
- Prednimustine - administration & dosage
- Prednimustine - adverse effects
- Remission Induction -
- Survival Rate -
- Thrombocytopenia - chemically induced
- Vomiting - chemically induced