Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hofmann, E; Fink, J; Pignet, AL; Schwarz, A; Schellnegger, M; Nischwitz, SP; Holzer-Geissler, JCJ; Kamolz, LP; Kotzbeck, P.
Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders.
Biomedicines. 2023; 11(4):
Doi: 10.3390/biomedicines11041056
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- Leading authors Med Uni Graz
- Fink Julia
- Hofmann Elisabeth
- Kotzbeck Petra
- Co-authors Med Uni Graz
- Geißler Judith Christine Julie
- Kamolz Lars-Peter
- Nischwitz Sebastian
- Pignet Anna-Lisa
- Schellnegger Marlies
- Schwarz Anna
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- Abstract:
- Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting.
- Find related publications in this database (Keywords)
- in vitro skin models
- in vitro wound healing
- chronic wounds
- hypertrophic scars
- keloids