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Zafaranieh, S; Stadler, JT; Pammer, A; Marsche, G; van Poppel, MNM; Desoye, G; Dali Core Investigator Group.
The Association of Physical Activity and Sedentary Behavior with Maternal and Cord Blood Anti-Oxidative Capacity and HDL Functionality: Findings of DALI Study.
Antioxidants (Basel). 2023; 12(4): 827 Doi: 10.3390/antiox12040827 [OPEN ACCESS]
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Leading authors Med Uni Graz: Van Poppel Mireille Nicoline Maria
Co-authors Med Uni Graz: Desoye Gernot; Marsche Gunther; Pammer Anja; Stadler Julia
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Abstract:: Obesity is one of the most common health issues in pregnancy with short and long-term consequences for both mother and her offspring. Promoting moderate to vigorous physical activity (MVPA) and decreasing sedentary time (ST) could have a positive impact on weight and obesity management, and therefore adiposity-induced oxidative stress, inflammation, and atherogenesis. However, the effects of MVPA and ST on anti-oxidative and anti-atherogenic markers in pregnancy have not been studied to date. This study aimed to assess the association of longitudinally and objectively measured MVPA and ST in 122 overweight/obese women (BMI ≥ 29 kg/m²) with maternal and cord blood markers of oxidative stress measured by advanced oxidation protein products (AOPP), anti-oxidative capacity, as well as high-density lipoproteins (HDL) related paraoxonase-1 (PON-1) activity and cholesterol efflux. Linear regression models showed no associations of MVPA and ST with outcomes in maternal blood. In contrast, MVPA at <20 weeks and 24-28 weeks of gestation were positively associated with anti-oxidative capacity, as well as PON-1 activity of HDL in cord blood. MVPA at 35-37 weeks correlated with higher AOPP, as well as higher anti-oxidative capacity. ST <20 weeks was also positively associated with inhibition of oxidation in cord blood. We speculate that increasing MVPA of overweight/obese women during pregnancy attenuates the oxidative stress state in the new-born.
Find related publications in this database (Keywords): obesity; pregnancy; antioxidative capacity; physical activity; sedentary behavior; cholesterol efflux