Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nizet, S; Rieger, J; Sarabi, A; Lajtai, G; Zatloukal, K; Tschegg, C.
Binding and inactivation of human coronaviruses, including SARS-CoV-2, onto purified clinoptilolite-tuff.
Sci Rep. 2023; 13(1): 4673
Doi: 10.1038/s41598-023-31744-z
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- Co-Autor*innen der Med Uni Graz
- Kircher Julia
- Zatloukal Kurt
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- Abstract:
- The current COVID19 pandemic is caused by a positive-sense single-stranded RNA virus, which presents high mutational rates. The development of effective therapeutics and mitigation strategies using vaccination or therapeutic antibodies faces serious challenges because of the regular emergence of immune escape variants of the virus. An efficient approach would involve the use of an agent to non-specifically limit or block viruses contacting the mucosae and therefore entering the body. Here, we investigated the ability of a micronized purified clinoptilolite-tuff to bind and neutralize different viruses from the Coronaviridae family. Using plaque assay, RT-qPCR and immunostaining, the adsorption and inactivation of the seasonal human coronavirus HCoV-229E and of 2 SARS-CoV-2 variants were demonstrated. The resulting data suggest that purified clinoptilolite-tuff could be used as an ingredient in new medical devices and/or pharmaceuticals to prevent or mitigate SARS-CoV-2 dissemination.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- SARS-CoV-2 - administration & dosage
- COVID-19 - administration & dosage
- Coronaviridae - administration & dosage