Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Senner, F; Hiendl, L; Bengesser, S; Adorjan, K; Anghelescu, IG; Baune, BT; Budde, M; Dannlowski, U; Dietrich, DE; Falkai, P; Fallgatter, AJ; Hasan, A; Heilbronner, M; Jäger, M; Juckel, G; Kalman, JL; Konrad, C; Kohshour, MO; Papiol, S; Reich-Erkelenz, D; Reimer, J; Schaupp, SK; Schmauß, M; Senner, S; Spitzer, C; Vogl, T; Zimmermann, J; Heilbronner, U; Schulte, EC; Schulze, TG; Reininghaus, EZ; Kirchner, SK; Dalkner, N.
Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study.
Transl Psychiatry. 2023; 13(1): 99
Doi: 10.1038/s41398-023-02373-x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Bengesser Susanne
- Co-Autor*innen der Med Uni Graz
- Dalkner Nina
- Reininghaus Eva
- Vogl Thomas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatment adherence can prevent exacerbations and re-hospitalizations. To date, the relationship between medication adherence and cognitive performance is understudied. Therefore, this study investigated the relationship between medication adherence and cognitive performance by analyzing the data of 862 participants with schizophrenia-spectrum and bipolar disorders (mean [SD] age, 41.9 [12.48] years; 44.8% female) from a multicenter study (PsyCourse Study). Z-scores for three cognitive domains were calculated, global functioning was measured with the Global Assessment of Functioning Scale, and adherence was assessed by a self-rating questionnaire. We evaluated four multiple linear regression models and built three clusters with hierarchical cluster analyses. Higher adherence behavior (p < 0.001) was associated with better global functioning but showed no impact on the cognitive domains learning and memory, executive function, and psychomotor speed. The hierarchical cluster analysis resulted in three clusters with different cognitive performances, but patients in all clusters showed similar adherence behavior. The study identified cognitive subgroups independent of diagnoses, but no differences were found in the adherence behavior of the patients in these new clusters. In summary, medication adherence was associated with global but not cognitive functioning in patients with schizophrenia-spectrum and bipolar disorders. In both diagnostic groups, cognitive function might be influenced by various factors but not medication adherence.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Adult - administration & dosage
- Male - administration & dosage
- Schizophrenia - drug therapy, diagnosis
- Bipolar Disorder - diagnosis
- Executive Function - administration & dosage
- Cognition - administration & dosage
- Multivariate Analysis - administration & dosage
- Neuropsychological Tests - administration & dosage