Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Richter, MJ; Fortuni, F; Alenezi, F; D'Alto, M; Badagliacca, R; Brunner, NW; van, Dijk, AP; Douschan, P; Gall, H; Ghio, S; Giudice, FL; Grünig, E; Haddad, F; Howard, L; Rajagopal, S; Stens, N; Stolfo, D; Thijssen, DHJ; Vizza, CD; Zamanian, RT; Zhong, L; Seeger, W; Ghofrani, HA; Tello, K.
Imaging the right atrium in pulmonary hypertension: A systematic review and meta-analysis.
J Heart Lung Transplant. 2023; 42(4):433-446
Doi: 10.1016/j.healun.2022.11.007
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Douschan Philipp
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- Abstract:
- BACKGROUND: Right atrial (RA) imaging has emerged as a promising tool for the evaluation of patients with pulmonary hypertension (PH), albeit without systematic validation. METHODS: PubMed, Web of Science and the Cochrane library were searched for studies investigating the prognostic value of RA imaging assessment in patients with PH from 2000 to June 2021 (PROSPERO Identifier: CRD42020212850). An inverse variance-weighted meta-analysis of univariable hazard ratios (HRs) was performed using a random effects model. RESULTS: Thirty-five studies were included (3,476 patients with PH; 74% female, 86% pulmonary arterial hypertension). Risk of bias was low/moderate (Quality of Prognosis Studies checklist). RA area (HR 1.06; 95% confidence interval [CI] 1.04-1.08), RA indexed area (HR 1.09; 95% CI 1.04-1.14), RA peak longitudinal strain (PLS; HR 0.94; 95% CI 0.91-0.97) and RA total emptying fraction (HR 0.96; 95% CI 0.94-0.98) were significantly associated with combined end-points including death, clinical worsening and/or lung transplantation; RA volume and volume index showed marginal significant associations. RA area (HR 1.06; 95% CI 1.04-1.07), RA indexed area (HR 1.12; 95% CI 1.07-1.17) and RA PLS (HR 0.98; 95% CI 0.97-0.99) showed significant associations with mortality; RA total emptying fraction showed a marginal association. CONCLUSIONS: Imaging-based RA assessment qualifies as a relevant prognostic marker in PH. RA area reliably predicts composite end-points and mortality, which underscores its clinical utility. RA PLS emerged as a promising imaging measure, but is currently limited by the number of studies and different acquisition methods.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Female - administration & dosage
- Male - administration & dosage
- Hypertension, Pulmonary - diagnostic imaging
- Heart Atria - diagnostic imaging
- Prognosis - administration & dosage
- Echocardiography - methods
- Atrial Appendage - administration & dosage
- Find related publications in this database (Keywords)
- Imaging
- meta-analysis
- right atrium
- pulmonary hypertension
- outcome
- systematic review