Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Schleiger, A; Kramer, P; Sallmon, H; Jentsch, N; Pileckaite, M; Danne, F; Schafstedde, M; Müller, HP; Müller, T; Tacke, F; Jara, M; Stockmann, M; Berger, F; Ovroutski, S.
Functional hepatic deterioration determined by ¹³C-methacetin breath test is associated with impaired hemodynamics and late Fontan failure in adults.
Front Cardiovasc Med. 2022; 9:952080 Doi: 10.3389/fcvm.2022.952080 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Sallmon Hannes
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: BACKGROUND: Despite improved survival a substantial number of Fontan patients eventually develop late failure. Fontan-associated liver disease (FALD) is the most frequent end-organ dysfunction. Although impaired hemodynamics and Fontan failure correlate with FALD severity, no association between hepatic functional metabolic impairment and Fontan hemodynamics has been established. HYPOTHESIS: Metabolic liver function measured by liver maximum function capacity test (LiMAx®) correlates with Fontan hemodynamics and Fontan failure. METHODS: From 2020 to 2022, 58 adult Fontan patients [median age: 29.3 years, IQR (12.7), median follow-up time after Fontan operation: 23.2 years, IQR (8.7)] were analyzed in a cross-sectional study. Hemodynamic assessment included echocardiography, cardiopulmonary exercise testing and invasive hemodynamic evaluation. Fontan failure was defined based on commonly applied clinical criteria and our recently composed multimodal Fontan failure score. RESULTS: LiMAx® test revealed normal maximum liver function capacity in 40 patients (>315 μg/h^*kg). In 18 patients a mild to moderate impairment was detected (140-314 μg/h^*kg), no patient suffered from severe hepatic deterioration (≤ 139 μg/kg^*h). Fontan failure was present in 15 patients. Metabolic liver function was significantly reduced in patients with increased pulmonary artery pressure (p = 0.041. r = -0.269) and ventricular end-diastolic pressure (p = 0.033, r = -0.325), respectively. In addition, maximum liver function capacity was significantly impaired in patients with late Fontan failure (289.0 ± 99.6 μg/kg^*h vs. 384.5 ± 128.6 μg/kg^*h, p = 0.007). CONCLUSION: Maximum liver function capacity as determined by LiMAx® was significantly reduced in patients with late Fontan failure. In addition, elevated pulmonary artery pressure and end-diastolic ventricular pressure were associated with hepatic functional metabolic impairment.
Find related publications in this database (Keywords): late Fontan failure; Fontan-associated liver disease; end-organ dysfunction; Fontan hemodynamics; metabolic liver function