Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hofmann, E; Schwarz, A; Fink, J; Kamolz, LP; Kotzbeck, P.
Modelling the Complexity of Human Skin In Vitro.
Biomedicines. 2023; 11(3):
Doi: 10.3390/biomedicines11030794
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- Führende Autor*innen der Med Uni Graz
- Hofmann Elisabeth
- Kotzbeck Petra
- Schwarz Anna
- Co-Autor*innen der Med Uni Graz
- Fink Julia
- Kamolz Lars-Peter
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- Abstract:
- The skin serves as an important barrier protecting the body from physical, chemical and pathogenic hazards as well as regulating the bi-directional transport of water, ions and nutrients. In order to improve the knowledge on skin structure and function as well as on skin diseases, animal experiments are often employed, but anatomical as well as physiological interspecies differences may result in poor translatability of animal-based data to the clinical situation. In vitro models, such as human reconstructed epidermis or full skin equivalents, are valuable alternatives to animal experiments. Enormous advances have been achieved in establishing skin models of increasing complexity in the past. In this review, human skin structures are described as well as the fast evolving technologies developed to reconstruct the complexity of human skin structures in vitro.
- Find related publications in this database (Keywords)
- in vitro skin models
- reconstructed human epidermis
- human skin equivalent