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Cremer, M; Sallmon, H; Kling, PJ; Bührer, C; Dame, C.
Thrombocytopenia and platelet transfusion in the neonate.
Semin Fetal Neonatal Med. 2016; 21(1):10-8 Doi: 10.1016/j.siny.2015.11.001
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Co-authors Med Uni Graz: Sallmon Hannes
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Abstract:: Neonatal thrombocytopenia is widespread in preterm and term neonates admitted to neonatal intensive care units, with up to one-third of infants demonstrating platelet counts <150 × 10(9)/L. Thrombocytopenia may arise from maternal, placental or fetal/neonatal origins featuring decreased platelet production, increased consumption, or both mechanisms. Over the past years, innovations in managing neonatal thrombocytopenia were achieved from prospectively obtained clinical data on thrombocytopenia and bleeding events, animal studies on platelet life span and production rate and clinical use of fully automated measurement of reticulated platelets (immature platelet fraction). This review summarizes the pathophysiology of neonatal thrombocytopenia, current management including platelet transfusion thresholds and recent developments in megakaryopoietic agents. Furthermore, we propose a novel index score for bleeding risk in thrombocytopenic neonates to facilitate clinician's decision-making when to transfuse platelets.
Find related publications in this database (using NLM MeSH Indexing): Benzoates - therapeutic use; Clinical Decision-Making - administration & dosage; Hematologic Agents - therapeutic use; Humans - administration & dosage; Hydrazines - therapeutic use; Infant, Newborn - administration & dosage; Intensive Care, Neonatal - administration & dosage; Platelet Transfusion - methods, standards; Pyrazoles - therapeutic use; Receptors, Fc - therapeutic use; Recombinant Fusion Proteins - therapeutic use; Thrombocytopenia - diagnosis, etiology, physiopathology, therapy; Thrombopoiesis - physiology; Thrombopoietin - therapeutic use
Find related publications in this database (Keywords): Bleeding index; Hemorrhage; Megakaryopoiesis; Platelet function; Preterm; Immature platelets; Reticulated platelets