Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Raschzok, N; Sallmon, H; Pratschke, J; Sauer, IM.
MicroRNAs in liver tissue engineering - New promises for failing organs.
Adv Drug Deliv Rev. 2015; 88:67-77
Doi: 10.1016/j.addr.2015.06.005
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Sallmon Hannes
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- Abstract:
- miRNA-based technologies provide attractive tools for several liver tissue engineering approaches. Herein, we review the current state of miRNA applications in liver tissue engineering. Several miRNAs have been implicated in hepatic disease and proper hepatocyte function. However, the clinical translation of these findings into tissue engineering has just begun. miRNAs have been successfully used to induce proliferation of mature hepatocytes and improve the differentiation of hepatic precursor cells. Nonetheless, miRNA-based approaches beyond cell generation have not yet entered preclinical or clinical investigations. Moreover, miRNA-based concepts for the biliary tree have yet to be developed. Further research on miRNA based modifications, however, holds the promise of enabling significant improvements to liver tissue engineering approaches due to their ability to regulate and fine-tune all biological processes relevant to hepatic tissue engineering, such as proliferation, differentiation, growth, and cell function.
- Find related publications in this database (using NLM MeSH Indexing)
- Biliary Tract - metabolism
- Cell Differentiation - physiology
- Hepatocytes - metabolism
- Humans - administration & dosage
- Liver - metabolism
- MicroRNAs - metabolism
- Tissue Engineering - methods
- Find related publications in this database (Keywords)
- MicroRNA
- Liver tissue engineering
- Liver transplantation