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SHR Neuro Cancer Cardio Lipid Metab Microb
Sallmon, H; Sola-Visner, M.
Clinical and research issues in neonatal anemia and thrombocytopenia.
Curr Opin Pediatr. 2012; 24(1):16-22
Doi: 10.1097/MOP.0b013e32834ee5cc
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Sallmon Hannes
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- Abstract:
- PURPOSE OF REVIEW: Anemia and thrombocytopenia are the most common hematological problems in neonates. Red blood cell (RBC) and platelet transfusions are the mainstays of therapy, but data to guide neonatal transfusion practices have been sparse. Recombinant hematopoietic growth factors represent another therapeutic alternative, but their use in this population requires a solid understanding of the developmental differences between fetal and adult hematopoiesis. RECENT FINDINGS: Recently, follow-up studies from children randomized as neonates to either liberal or restrictive RBC transfusion approaches were published. Results of these studies have so far been contradictory and have generated more questions than answers. New developmental stage-specific problems associated with RBC transfusions were also uncovered, such as the transfusion-associated necrotizing enterocolitis. Finally, two thrombopoietin (Tpo) mimetics were approved by the FDA for the treatment of adults with chronic immune thrombocytopenia, thus offering a novel potential therapeutic alternative for thrombocytopenic neonates. SUMMARY: In this review, we will discuss the currently available data regarding neonatal RBC and platelet transfusion thresholds, as well as the potential limitations, and concerns associated with the use of erythropoietin and Tpo mimetics in this patient population. Finally, we will point out specific areas wherein additional research is critically needed.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Anemia, Neonatal - diagnosis, embryology, therapy
- Erythrocyte Transfusion - trends
- Follow-Up Studies - administration & dosage
- Guidelines as Topic - administration & dosage
- Humans - administration & dosage
- Infant - administration & dosage
- Infant, Newborn - administration & dosage
- Platelet Count - administration & dosage
- Platelet Transfusion - trends
- Randomized Controlled Trials as Topic - administration & dosage
- Thrombocytopenia - diagnosis, epidemiology, therapy
- Thrombopoietin - blood
- Find related publications in this database (Keywords)
- anemia of prematurity
- erythropoietin
- neonatal thrombocytopenia
- thrombopoietin
- transfusions