Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Raschzok, N; Reutzel-Selke, A; Schmuck, RB; Tannus, LM; Morgul, MH; Dietel, C; Leder, A; Struecker, B; Lippert, S; Sallmon, H; Schmelzle, M; Bartels, M; Jonas, S; Pratschke, J; Sauer, IM.
microRNA signatures in peripheral blood fail to detect acute cellular rejection after liver transplantation.
Biomarkers. 2016; 21(8):699-707
Doi: 10.3109/1354750X.2016.1172113
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Sallmon Hannes
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- Abstract:
- OBJECTIVE: We investigated whether microRNA signatures in whole blood samples are associated with acute cellular rejection (ACR) after liver transplantation. MATERIALS AND METHODS: Blood samples were collected using Paxgene technology and analyzed by microarrays and quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: microRNA signatures failed to distinguish between 19 patients with ACR and 16 controls. Let-7b-5p and let-7c were upregulated in a subgroup of patients with ACR during the 6th and 7th postoperative days but failed in an independent validation of 20 patients. CONCLUSION: microRNA signatures in whole blood processed by Paxgene technology are not suited for the detection of ACR after liver transplantation.
- Find related publications in this database (Keywords)
- Allograft
- biomarker
- Paxgene