Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Werthebach, M; Stewart, FA; Gahlen, A; Mettler-Altmann, T; Akhtar, I; Maas-Enriquez, K; Droste, A; Eichmann, TO; Poschmann, G; Stühler, K; Beller, M.
Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf.
Cell Rep. 2019; 26(13): 3726-3740.e7. Doi: 10.1016/j.celrep.2019.02.110
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Eichmann Thomas
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Abstract:: Lipid droplets (LDs) are the universal cellular storage organelles for esterified neutral lipids. The increasing number of characterized LD-associated proteins attained LDs with hitherto unexpected functions on top of their classical role as energy depot. Here, we characterize the LD-associated protein CG9186 of Drosophila by a CRISPR/Cas9-derived mutant fly line. While the mutant flies only showed a mild triacylglycerol storage phenotype, they were highly protected from desiccation stress, likely linked to a reduced locomotor activity and altered cuticular hydrocarbons. Both parameters depend on juvenile hormone (JH) signaling. Together with an observed interaction between CG9186 and JH-degrading enzymes, our results suggest that CG9186 participates in endocrine physiology regulation. In support of this hypothesis, CG9186 mutant flies show an altered expression of JH target genes and fail to adjust their developmental rate to dietary yeast-to-sugar ratio changes. Our results thus link LDs to organismic physiology regulation.
Find related publications in this database (using NLM MeSH Indexing): Animals - administration & dosage; Body Size - administration & dosage; Carboxylic Ester Hydrolases - genetics, metabolism; Diet - administration & dosage; Drosophila Proteins - genetics, metabolism; Drosophila melanogaster - administration & dosage; Gene Expression Regulation, Developmental - administration & dosage; Insulin - metabolism; Juvenile Hormones - genetics, metabolism; Lipid Droplets - metabolism; Locomotion - administration & dosage; Mutation - administration & dosage; Signal Transduction - administration & dosage; Triglycerides - metabolism