Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Perwein, T; Giese, B; Nussbaumer, G; von, Bueren, AO; van, Buiren, M; Benesch, M; Kramm, CM.
How I treat recurrent pediatric high-grade glioma (pHGG): a Europe-wide survey study.
J Neurooncol. 2023; 161(3):525-538
Doi: 10.1007/s11060-023-04241-6
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- Führende Autor*innen der Med Uni Graz
- Perwein Thomas
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Nussbaumer Gunther
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- Abstract:
- PURPOSE: As there is no standard of care treatment for recurrent/progressing pediatric high-grade gliomas (pHGG), we aimed to gain an overview of different treatment strategies. METHODS: In a web-based questionnaire, members of the SIOPE-BTG and the GPOH were surveyed on therapeutic options in four case scenarios (children/adolescents with recurrent/progressing HGG). RESULTS: 139 clinicians with experience in pediatric neuro-oncology from 22 European countries participated in the survey. Most respondents preferred further oncological treatment in three out of four cases and chose palliative care in one case with marked symptoms. Depending on the case, 8-92% would initiate a re-resection (preferably hemispheric pHGG), combined with molecular diagnostics. Throughout all case scenarios, 55-77% recommended (re-)irradiation, preferably local radiotherapy > 20 Gy. Most respondents would participate in clinical trials and use targeted therapy (79-99%), depending on molecular genetic findings (BRAF alterations: BRAF/MEK inhibitor, 64-88%; EGFR overexpression: anti-EGFR treatment, 46%; CDKN2A deletion: CDK inhibitor, 18%; SMARCB1 deletion: EZH2 inhibitor, 12%). 31-72% would administer chemotherapy (CCNU, 17%; PCV, 8%; temozolomide, 19%; oral etoposide/trofosfamide, 8%), and 20-69% proposed immunotherapy (checkpoint inhibitors, 30%; tumor vaccines, 16%). Depending on the individual case, respondents would also include bevacizumab (6-18%), HDAC inhibitors (4-15%), tumor-treating fields (1-26%), and intraventricular chemotherapy (4-24%). CONCLUSION: In each case, experts would combine conventional multimodal treatment concepts, including re-irradiation, with targeted therapy based on molecular genetic findings. International cooperative trials combining a (chemo-)therapy backbone with targeted therapy approaches for defined subgroups may help to gain valid clinical data and improve treatment in pediatric patients with recurrent/progressing HGG.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Humans - administration & dosage
- Child - administration & dosage
- Brain Neoplasms - therapy, drug therapy
- Proto-Oncogene Proteins B-raf - administration & dosage
- Glioma - therapy, drug therapy
- Temozolomide - therapeutic use
- Bevacizumab - therapeutic use
- Chronic Disease - administration & dosage
- Find related publications in this database (Keywords)
- Survey
- Treatment
- Recurrent
- Progressing
- Pediatric HGG