Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jonak, C; Göttfried, I; Perl-Convalexius, S; Gruber, B; Schütz-Bergmayr, M; Vujic, I; Weger, W; Schicher, N; Semlin, L; Hemetsberger, M; Cordey, M; Sator, P.
Characteristics and outcomes of patients with psoriasis treated with apremilast in the real-world in Austria - results the APPRECIATE study.
Ther Adv Chronic Dis. 2023; 14: 20406223231152785
Doi: 10.1177/20406223231152785
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- Co-Autor*innen der Med Uni Graz
- Weger Wolfgang
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- Abstract:
- BACKGROUND: Apremilast, an oral phosphodiesterase 4 inhibitor, is approved in the European Union for the treatment of moderate-to-severe chronic plaque psoriasis in adult patients refractory or contraindicated to or intolerant of other systemic therapies. OBJECTIVES: The APPRECIATE study assessed apremilast use in real-world practice and its clinical value to physicians and patients. APPRECIATE was a multinational, observational, retrospective, cross-sectional study. METHODS: Apremilast effectiveness at 6 (±1) months was assessed on the basis of psoriasis severity and health-related quality-of-life scores and treatment satisfaction using physician/patient-reported outcomes, respectively. We report the Austrian cohort of 72 patients. RESULTS: At 6 (±1) months, three-quarters of patients remained on apremilast, while physicians and patients reported treatment benefits across all psoriasis symptoms and manifestations. Of patients, the majority were satisfied with their treatment and achieved treatment goals considered most relevant. Patients' and physicians' perceptions of treatment effectiveness were aligned, and health-related quality-of-life scores indicated an improvement in the majority of patients. Apremilast tolerability was consistent with the known safety profile. CONCLUSIONS: Among psoriasis patients receiving apremilast in Austria, improvement in clinical outcomes were observed and satisfaction with apremilast treatment among patients and physicians was high. REGISTRATION: ClinicalTrials.gov NCT02740218.
- Find related publications in this database (Keywords)
- apremilast
- health-related quality of life
- psoriasis drug therapy
- psoriasis severity scores
- real-world data