Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Löwensteyn, YN; Willemsen, JE; Mazur, NI; Scheltema, NM; van, Haastregt, NCJ; Buuren, AAAT; van, Roessel, I; Scheepmaker, D; Nair, H; van, de, Ven, PM; Bont, LJ; on behalf of the RSV GOLD Study Group.
Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series.
Pediatr Infect Dis J. 2023; 42(1): 1-7.
Doi: 10.1097/INF.0000000000003747
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- Study Group Mitglieder der Med Uni Graz:
- Resch Bernhard
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- Abstract:
- BACKGROUND: According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies. MATERIALS: RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality. RESULTS: We included 231 nosocomial and 931 community-acquired RSV-related in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively). CONCLUSIONS: This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.
- Find related publications in this database (using NLM MeSH Indexing)
- Child - administration & dosage
- Humans - administration & dosage
- Infant, Newborn - administration & dosage
- Cross Infection - epidemiology
- Hospital Mortality - administration & dosage
- Hospitals - administration & dosage
- Research - administration & dosage
- Find related publications in this database (Keywords)
- respiratory syncytial virus
- nosocomial infection
- community-acquired infection
- child mortality
- global health