Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stelmaszynska, T; Kukovetz, E; Egger, G; Schaur, RJ.
Possible involvement of myeloperoxidase in lipid peroxidation.
INT J BIOCHEM. 1992; 24(1): 121-128.
Doi: 10.1016%2F0020-711X%2892%2990237-U
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- Co-Autor*innen der Med Uni Graz
- Egger Gerd
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- Abstract:
- 1. Exposure of liposomes to the MPO-H2O2-Cl- system results in oxidation of lipids. Malondialdehyde and 4-hydroxynonenal are formed. 2. Oxidation of liposomes by stimulated rat neutrophils, assessed by malondialdehyde formation, is inhibited by KCN. This indicates involvement of MPO in the process. 3. The MPO-H2O2 system oxidizes mildly LDL but in the presence of chloride a propagation phase, with a rapid increase of conjugated diene formation, was observed.
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- Potassium Chloride - pharmacology
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