Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fölsch, B; Gabriel, C; Wilders-Truschnig, MM; Lanzer, G.
Possibilities and limits of anti-HCV antibody screening in the blood donation service].
Infusionsther Transfusionsmed. 1994; 21(6):388-392
Doi: 10.1159/000223017
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- GABRIEL Christian
- Lanzer Gerhard
- Truschnig-Wilders Martini
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- Abstract:
- Hepatitis C virus (HCV) is responsible for the majority of post-transfusion hepatitis cases. We compared the correlation and reproducibility of different screening and confirmatory tests. 1,406 samples of voluntary blood donors were tested in parallel using 3 enzyme-linked immuno sorbent assays (ELISA) for HCV antibodies. Those samples that were positive in at least 1 of the 3 tests were additionally tested in a 3rd-generation ELISA as well as in 3 different confirmatory tests. 13 samples (0.92%) were repeat reactive in at least 1 of the ELISAs with different results in the confirmatory tests. Only 3 samples (0.21%) with high sample/cutoff ratios in the ELISAs were positive in all 3 confirmatory tests. The reproducibility of the tested ELISAs and the correlation with confirmatory tests were good only in samples with a high signal to cutoff ratio. Two different high-positive ELISA results can be regarded as confirmation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged - epidemiology
- Blood Banks - statistics & numerical data
- Blood Donors - statistics & numerical data
- Blood Transfusion - statistics & numerical data
- Blood-Borne Pathogens -
- Cross-Sectional Studies -
- Enzyme-Linked Immunosorbent Assay -
- Female -
- Hepatitis Antibodies - blood
- Hepatitis C - epidemiology Hepatitis C - prevention & control Hepatitis C - transmission
- Hepatitis C Antibodies -
- Humans -
- Incidence -
- Male -
- Middle Aged -
- Reproducibility of Results -
- Risk Factors -
- Find related publications in this database (Keywords)
- Hepatitis C Virus
- Blood Donor Screening
- Enzyme-Linked Immunosorbent Assay